An Expedient Stereoselective Synthesis of Spirocyclopropyl Oxindoles from Indolin‐2‐One/N‐Protected Indolin‐2‐Ones and Bromonitroalkenes |
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| Authors: | Suparna Roy Kwunmin Chen |
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| Institution: | Chemistry Department, National Taiwan Normal University, 88 Sec. 4, TingChow Rd., Taipei 116, Taiwan, R.O.C. |
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| Abstract: | A direct and much simpler way was developed for the diastereoselective synthesis of spiro cyclopropan‐1,3′‐oxindoles from indolin‐2‐one/N‐protected indolin‐2‐ones and bromonitroalkene. The fused restrained cyclopropanes were obtained with high diastereomeric ratios (upto >99:1) and in reasonable to high isolated chemical yields (upto 94%). |
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| Keywords: | Bromonitroalkene Oxindole Cyclopropanation Diastereoselectivity |
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