Organic Stereochemistry. Part 6 |
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Authors: | Giulio Vistoli Bernard Testa Alessandro Pedretti |
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Institution: | 1. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli, 25, I‐20133 Milano;2. Department of Pharmacy, Lausanne University Hospital (CHUV), Rue du Bugnon, CH‐1011 Lausanne |
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Abstract: | Following the previous Part on the mechanisms of chiral recognition in pharmacology, the road was open to cover one aspect of stereoselectivity that had been evoked in Part 5 but not discussed explicitly, namely the pharmacological significance of the conformational behavior of active molecules. There, we saw how ligands and binding sites adapt to each other, but these results were not related explicitly to the conformational behavior of the ligand. The focus of the present Part is to use a few well‐known drugs, examine their conformational behavior, compare the 3D geometry of probable conformers with rigid analogs acting at the same receptor, and reflect on the concept of ‘active conformation’. |
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Keywords: | Stereochemistry Symmetry elements Molecular pharmacology |
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