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Evaluation of Antifungal and Antioxidant Activity of Newly Synthesized 4‐Thiazolidinones |
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| Authors: | Nabil Abdul‐Kader Saleh Hussein El‐Abd Saltani Fadhil Abbas Al‐Issa Ahmad Abul‐kasem Errabie Al‐Sadek Gomaa Melad |
| Affiliation: | 1. Chemistry Department, Faculty of Science, Tripoli University, Tripoli, Libya;2. Chemistry Department, Faculty of Education (Kasr Ben‐Ghashier), Tripoli University, Tripoli, Libya |
| Abstract: | The antifungal and antioxidant activities of thirty newly synthesized 4‐thiazolidinone (TZON) derivatives were assessed against some fungal species including Candida albicans and Aspergillus niger. The introduction of different arylidene moieties at 5‐positions of the thiazolidinone ring successfully enhanced its biological activity. The structure–activity relationships revealed that 4‐thiazolidinone derivatives harboring dicarboxyethyl (at the 2‐ethenyl) and p‐nitrophenylhydrazyl arm (at the 5‐arylidine positions of the thiazolidinone ring) display considerable antifungal and antioxidant properties. |
| Keywords: | 4‐Thiazolidinone derivatives Antifungal Antioxidant activity |