Synthesis of Tetradentate Schiff Base Derivatives of Transition Bimetallic Complexes as Antimicrobial Agents |
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Authors: | Muhammad Yousaf Muhammad Pervaiz Muhammad Sagir Ashhar‐uz Zaman Muhammad Mushtaq Muhammad Yasin Naz |
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Institution: | 1. Department of Chemistry, Government College University, Faisalabad, Pakistan;2. Department of Chemical Engineering, Universiti Teknologi PETRONAS, Bandar Seri Iskandar, 31750 Tronoh, Perak, Malaysia;3. Institute of Chemistry, University of the Punjab, Lahore, Pakistan;4. Department of Physics, University of Agriculture, Faisalabad, Pakistan |
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Abstract: | A series of Co(II), Cu(II), Mn(II) and Zn(II) bimetallic complexes have been synthesized with the schiff base ligand 2‐(bis‐2‐hydroxyl phenylidene) diimine (L) derived from the condensation of hydrazine and salicylaldehyde. The synthesized ligand and bimetallic complexes were characterized by different spectroscopic techniques. The characterization of ligand was carried out by FT‐IR, H1NMR, C13NMR and MS while the bimetallic complexes were characterized by FT‐IR and X‐ray crystallographic techniques. The complexes and ligand were employed in vitro for antifungal and antibacterial activities using disc diffusion method. Different fungal strains such as Alternaria Alternate, Aspergillus Flavus and Aspergillus Niger were used to check antifungal activities of bimetallic complexes and ligand. Similarly, the bacterial strains used were Staphylococcus Aureus, Bacillus Subbtilis and Escheria Coli. The biological studies showed that the ligand exhibited lower value of antifungal and antibacterial activities than bimetallic complexes. |
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Keywords: | Schiff base Transition metals Hydrazine Salicylaldehyde Bacterial strains Fungal strains |
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