Juglanones A and B: Two Novel Tetralone Dimers from Walnut Pericarp (Juglans regia) |
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| Authors: | Cong‐Ying Li Hong‐Jian Du Xue‐Hui Su Yu‐Jiao Zhong Zhi‐Peng Yuan Yan‐Fang Li Bing Liang |
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| Institution: | Department of Pharmaceutics and Bioengineering, School of Chemical Engineering, Sichuan University, Chengdu 610065, P.?R. China, (phone/fax: +86‐28‐85405221) |
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| Abstract: | Two novel tetralone dimers, with an O‐bridge, named juglanones A and B ( 1 and 2 , resp.), were isolated from the AcOEt extract of walnut pericarps. These compounds are the first examples of O‐bridged dimeric tetralones. Their structures were determined by spectroscopic methods, including HR‐TOF‐MS, and 1D‐ and 2D‐NMR. Biological evaluation of these two isolates against a number of human cancer cell lines is also described. |
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| Keywords: | Juglans regia Juglanones A and B Tetralone dimers Cytotoxic activity |
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