Crotofolane‐ and Casbane‐Type Diterpenes from Croton argyrophyllus |
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| Authors: | Francisco Artur e Silva Filho José Nunes da Silva Junior Carlos Alberto de Simone Edilberto Rocha Silveira Mary Anne Sousa Lima |
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| Affiliation: | 1. Departamento de Química Organica e Inorganica, Centro de Ciências, Universidade Federal do Ceará, CP 12.200, CEP 60.021?–?940, Fortaleza, CE, Brazil (phone/fax: +55?08533669782);2. Universidade Federal de Alagoas, Instituto de Química e Biotecnologia, CEP 57072‐970, Maceió, AL, Brazil |
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| Abstract: | Phytochemical analysis of Croton argyrophyllus led to the isolation of five new diterpenes named (5β,6β)‐5,6 : 13,16‐diepoxycrotofola‐4(9),10(18),13,15‐tetraen‐1‐one ( 1 ), (5β,6β)‐5,6 : 13,16‐diepoxy‐2‐epicrotofola‐4(9),10(18),13,15‐tetraen‐1‐one ( 2 ), (5β,6β)‐5,6 : 13,16‐diepoxy‐16‐hydroxy‐2‐epicrotofola‐4(9),10(18),13,15‐tetraen‐1‐one ( 3 ), (5β,6β)‐5,6 : 13,16‐diepoxy‐16‐hydroxy‐2‐epicrotofola‐4(9), 10(18),13,15‐tetraen‐1‐one ( 4 ) and (2E,5β,6E,12E)‐5‐hydroxycasba‐2,6,12‐trien‐4‐one ( 5 ), in addition to the known diterpenes crotonepetin and depressin, and acetylaleuritolic acid and spinasterol. The structures of the isolated compounds were established by a combination of spectroscopic methods, including HR‐ESI‐MS, 2D‐NMR, and X‐ray crystallography. |
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| Keywords: | Croton argyrophyllus Diterpenes Casbanes Crotofolanes X‐Ray crystallography |
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