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Differential Pulse Voltammetric Determination of Montelukast in Tablets and Human Plasma by Using Chitosan Modified Carbon Paste Electrode |
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| Authors: | Gülcemal Yıldız Zeynep Aydoğmuş Jean‐Michel Kauffmann |
| Institution: | 1. Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, 34469 Maslak, Istanbul, Turkey;2. Department of Analytical Chemistry, Faculty of Pharmacy, Istanbul University, 34116, Beyaz?t, Istanbul, Turkey tel: +90?212?440?0261;3. fax: +90?212?440?0252;4. Université Libre de Bruxelles, Pharmaceutical Institute, Campus Plaine CP 205/6, Bd du Triomphe, B‐1050 Brussels, Belgium |
| Abstract: | Electrochemical reduction and determination of montelukast (MKS) was studied in methanol – 0.1 M HCl solution (1 : 1, v/v) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at chitosan modified carbon paste electrode. The linear range was 1.70×10?7–1.83×10?5 M for DPV analysis. Limit of detection (LOD) and limit of quantification (LOQ) were 5.32×10?8 M and 1.61×10?7 M, respectively. The developed method was successfully applied to the determination of MKS in tablets and spiked human plasma. The results obtained were in good agreement with those obtained using a reported spectrofluorimetric technique. |
| Keywords: | Montelukast Voltammetry Chitosan modified carbon paste electrode Drugs Plasma |