Novel Cerebrosides Isolated from the Fermentation Mycelia of Tuber indicum |
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| Authors: | Yuan‐Yuan Li Ping Liu Yang Tang Hong‐Mei Li Ya‐Ling Tang Xin‐Hua Liang Ya‐Jie Tang |
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| Institution: | 1. Key Laboratory of Fermentation Engineering (Minister of Education), Hubei University of Technology, Wuhan 430068, P.?R. China (phone/fax: +86‐27‐88015108);2. Research Group for Bioactive Products, Department of Biology & Chemistry, City University of Hong Kong, Kowloon, Hong Kong SAR, P.?R. China;3. State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, P.?R. China;4. Laboratory of Synthetic Biology, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201203, P.?R. China |
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| Abstract: | The four new cerebrosides 1 – 4 possessing a unique C18 9‐methylsphinga‐4,8‐dienine‐related moiety and a cyclic octapeptide, 5 , possessing alternating proline and glycine moietes were isolated from the Tuber indicum fermentation mycelium. Their structures were established on the basis of a spectroscopic analysis including NMR and HR‐ESI‐MS, as well as an acidic methanolysis experiment. To the best of our knowledge, the cerebrosides identified in the present study are quite different from those isolated from Tuber indicum fruiting bodies. Additionally, it was the first time that a cyclic peptide was isolated from the Tuber genus. |
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| Keywords: | Tuber indicum Cerebrosides Cyclic peptides Peptides |
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