Lab‐on‐a‐Chip Sensor with Evaporated Bismuth Film Electrode for Anodic Stripping Voltammetry of Zinc |
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Authors: | Wenjing Kang Xing Pei Wei Yue Adam Bange William R. Heineman Ian Papautsky |
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Affiliation: | 1. BioMicroSystems Lab, Department of Electrical Engineering and Computing Systems, University of Cincinnati, Cincinnati, OH 45221 tel.: (513) 556‐2347;2. fax: (513) 556‐7326;3. Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221;4. Department of Chemistry, Xavier University, Cincinnati, OH 45221 |
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Abstract: | In this work, we report on the development of a lab‐on‐a‐chip electrochemical sensor that uses an evaporated bismuth electrode to detect zinc using square wave anodic stripping voltammetry. The microscale electrochemical cell consists of a bismuth working electrode, an integrated silver/silver chloride reference electrode, and a gold auxiliary electrode. The sensor exhibits a linear response in 0.1 M acetate buffer at pH 6 with zinc concentrations in the 1–30 μM range and a calculated detection limit of 60 nM. The sensor successfully detected zinc in a bovine serum extract and the results were corfirmed by independent AAS measurements. Our results demonstrate the advantageous qualities of this lab‐on‐a‐chip electrochemical sensor for clinical applications, which include small sample volume (µL scale), reduced cost, short response time and high accuracy at low concentrations of analyte. |
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Keywords: | Anodic stripping voltammetry Zinc Lab‐on‐a‐chip sensor Dopamine Evaporated Bi film electrode |
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