Electrochemical Determination of the Anticancer Herbal Drug Shikonin at a Nanostructured Poly(hydroxymethylated‐3,4‐ethylenedioxythiophene) Modified Electrode |
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| Authors: | Liping Wu Limin Lu Long Zhang Jingkun Xu Kaixin Zhang Yangping Wen Xuemin Duan Fan Yang |
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| Affiliation: | 1. Jiangxi Key Labrotory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, P.?R. China, Tel: +86‐791‐88537967;2. fax: +86‐791‐83823320;3. College of Science, Jiangxi Agricultural University, Nanchang 330045, P.?R. China |
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| Abstract: | A simple and sensitive method is described for the electrochemical determination of shikonin, a widely used anti‐tumoral agent, based on its electrochemical oxidation at a nanostructured poly(hydroxymethylated‐3,4‐ethylenedioxy‐thiophene) (PEDOT‐MeOH) electrode, which was fabricated by a facile electropolymerization method. Compared with bare and poly(3,4‐ethylenedioxythiophene) (PEDOT) electrodes, the PEDOT‐MeOH film exhibited a distinctly higher activity for the electrooxidation of shikonin. The PEDOT‐MeOH electrode showed a wide linear response for shikonin in the concentration range from 1.0 nM to 10.0 µM with detection limit of 0.3 nM. Furthermore, the PEDOT‐MeOH electrode displayed high stability, good reproducibility and high sensitivity for the detection of shikonin. |
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| Keywords: | PEDOT‐MeOH Electropolymerization Shikonin Modified electrode Electrochemical determination |
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