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Facile One‐pot Synthesis of Substituted Dihydropyrrol‐2‐ones via Four‐component Domino Reaction of Amines,Dialkyl Acetylenedicarboxylates and Formaldehyde |
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| Authors: | Seyed Sajad Sajadikhah Nourallah Hazeri Malek Taher Maghsoodlou Sayyed Mostafa Habibi‐Khorassani |
| Affiliation: | 1. Department of Chemistry, Faculty of Sciences, Najafabad Branch, Islamic Azad University, Najafabad, PO Box 517, Esfahan, Iran;2. Department o f Chemistry, University of Sistan and Balu chestan, P.O. Box 98135‐674, Zahedan, Iran |
| Abstract: | A mild and efficient method for the one‐pot synthesis of substituted dihydropyrrol‐2‐one derivatives is described via four‐component domino reaction of amines, dialkyl acetylenedicarboxyaltes and formaldehyde in the presence of 1‐methyl‐2‐oxopyrrolidinium hydrogen sulfate ([Hpyro][HSO4]) as ionic liquid catalyst. This facile approach proceeded smoothly in good to high yields and pure products are separated from the reaction mixture by simple filtration. |
| Keywords: | Dihydropyrrol‐2‐one Heterocycle Ionic liquid 1‐Methyl‐2‐oxopyrrolidinium Hydrogen Sulfate |