Cytotoxic Diterpenoids from the Stem Bark of Annona squamosa L. |
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| Authors: | Chang‐Xin Zhou Li‐Rui Sun Feng Feng Jian‐Xia Mo Hong Zhu Bo Yang Qiao‐Jun He Li‐She Gan |
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| Institution: | 1. Institute of Modern Chinese Medicine (IMCM), College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P.?R. China (phone: +86‐571‐88208457;2. fax: +86‐571‐88208445);3. Department of Phytochemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, P.?R. China;4. Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P.?R. China |
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| Abstract: | Three new ent‐kaurane diterpenoids, (4α)‐19‐nor‐ent‐kaurane‐4,16,17‐triol ( 1 ), (4α,16α)‐17‐(acetyloxy)‐19‐nor‐ent‐kaurane‐4,16‐diol ( 2 ), and 17‐hydroxy‐ent‐kaur‐15‐en‐19‐al ( 3 ), together with 11 known compounds, were isolated from the stem bark of Annona squamosa L. The structures of 1 – 3 were identified by analysis of their spectroscopic data. All compounds were evaluated for cytotoxic activity against human lung cancer (95‐D) and ovarian cancer (A2780) cell lines, and compounds 3, 5, 7, 11 – 14 exhibited promising antiproliferative activities with IC50 values ranging from 0.38 to 34.66 μM . |
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| Keywords: | Annona squamosa ent‐Kauranes Cytotoxic activity |
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