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Electrochemical Phenylselenoetherification as a Key Step in the Synthesis of (±)‐Curcumene Ether |
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| Authors: | Dragana Stevanović Anka Pejović Ivan S. Damljanović Mirjana D. Vukićević Georgi Dobrikov Vladimir Dimitrov Marija S. Denić Niko S. Radulović Rastko D. Vukićević |
| Affiliation: | 1. Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovi?a 12, RS‐34000 Kragujevac (phone: +38134300286;2. fax: +38134335040);3. Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, S. Markovi?a 69, RS‐34000 Kragujevac;4. Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Bl. 9, Acad. G. Bonchev Str., BG‐1113 Sofia;5. Department of Chemistry, Faculty of Science and Mathematics, University of Ni?, Vi?egradska 33, RS‐18000 Ni? (phone: +381628049210;6. fax: +38118533014) |
| Abstract: | Two variants of a new pathway for the synthesis of (±)‐curcumene ether are described. The key steps in these procedures are intramolecular cyclizations of 6‐methyl‐2‐(4‐methylphenyl)hept‐6‐en‐2‐ol and 2‐methyl‐6‐(4‐methylphenyl)hept‐6‐en‐2‐ol by means of an electrochemically generated phenylselenyl cation. This synthetic approach provides significantly better yields than the previously reported protocols. |
| Keywords: | Curcumene ether Electroorganic syntheses Phenylselenoetherification Diselenide, diphenyl Cyclization reactions |