| 吉士脱酮的1H及13C NMR研究 |
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| 引用本文： | 盛宛云,白秀梅.吉士脱酮的1H及13C NMR研究[J].波谱学杂志,1999,16(1):64-69. |
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| 作者姓名： | 盛宛云 白秀梅 |
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| 作者单位： | 上海市计划生育科学研究所国家计划生育药具实验室, 上海 200032 |
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| 摘 要： | Gestodene是避孕药物18甲基炔诺酮的衍生物,动物实验表明它的孕激素活性为18甲基炔诺酮的3~5倍.本文采用各种2D NMR技术,包括:1H-1H COSY,1H-13C COSY和HMBC等,归属了它的1H和13C的谱线,并得到了有关质子间的偶合常数.
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| 关 键 词： | Gestodene 口服避孕药 二维核磁共振 谱线归属 |
| 收稿时间： | 1998-11-09 |
1H NMR AND 13C NMR STUDY ON GESTODENE |
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| Sheng Wanyun,Bai Xiumei.1H NMR AND 13C NMR STUDY ON GESTODENE[J].Chinese Journal of Magnetic Resonance,1999,16(1):64-69. |
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| Authors: | Sheng Wanyun Bai Xiumei |
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| Institution: | National Laboratory of Contraceptives and Devices Research Shanghai Institute of Planned Parenthood Research, Shanghai 200032 |
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| Abstract: | In this article, 1H and 13 C NMR spectra of Gestodene were analyzed by using two dimensional 1H 1H COSY, heteronuclear 1H 13 C shift correlation and HMBC, It was made possible to assign 1H and 13 C NMR spectra of Gestodene completely by combination of these techniques, Gestodene showed complex 1H signal around 1.4-2.6ppm and 13 C signals around 25.3-38.13ppm, This combination of techniques is applicable for assignment of highly overlapping signals, The HMBC spectra can provide valuable information for assignment of 1H and 13 C NMR signals, |
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| Keywords: | Gestodene |
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