| 紫杉醇治疗小鼠S180肉瘤的体内31P MRS研究 |
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| 引用本文： | 田建广,魏昌华,冯锐,李光玉,茹祥斌,杜泽涵. 紫杉醇治疗小鼠S180肉瘤的体内31P MRS研究[J]. 波谱学杂志, 1999, 16(1): 7-12 |
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| 作者姓名： | 田建广 魏昌华 冯锐 李光玉 茹祥斌 杜泽涵 |
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| 作者单位： | 1.军事医学科学院国家生物医学分析中心, 北京 100850;2.军事医学科学院毒物药物研究所, 北京 100850 |
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| 摘 要： | 为了研究紫杉醇治疗小鼠S180肉瘤的31P MRS参数的变化及这些参数的变化是否早于常规观察的瘤体积的变化.方法:利用表面线圈31P NMR方法,研究小鼠皮下接种的S180肉瘤.结果:用药48h后给药组的PCr/Pi、β-NTP/Pi、PME/β-NTP比值与对照组有显著性差别(P<0.05),而肿瘤体积在给药组和对照组之间无显著性差别,31P MRS参数的变化早于瘤体积变化.结论:小鼠S180肉瘤31P MRS不仅可以给出定量的结果,而且可以较早地显示出治疗的效果.
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| 关 键 词： | 紫杉醇 小鼠S180肉瘤 表面线圈 31P MRS |
| 收稿时间： | 1998-11-16 |
IN VIVO STUDIES OF TAXOL CHEMOTHERAPY IN A MOUSE S180 SARCOMA BY 31P MAGNETIC RESONANCE SPECTROSCOPY |
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| Tian Jianguang,Wei Changhua,Feng Rui,Li Guangyu,Ru Xiangbin,Du Zehan. IN VIVO STUDIES OF TAXOL CHEMOTHERAPY IN A MOUSE S180 SARCOMA BY 31P MAGNETIC RESONANCE SPECTROSCOPY[J]. Chinese Journal of Magnetic Resonance, 1999, 16(1): 7-12 |
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| Authors: | Tian Jianguang Wei Changhua Feng Rui Li Guangyu Ru Xiangbin Du Zehan |
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| Affiliation: | 1. National Center for Biomedical Analysis, Academy of Military Sciences, Beijing 100850;2. Institute of Pharmacology and Toxicology, Academy of Military Sciences, Beijing 100850 |
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| Abstract: | Objective:To study whether the changes of 31P MRS parameters of mouse S180 sarcoma treated by Taxol is earlier than the changes of tumor volume. Methods:Mouse S180 sarcoma (i.p.) was studied by using surface-coil 31P NMR. Results:After 48h following treatment, PCr/Pi and β-NTP/Pi ratios of treated groups are higher than those of control group (P <0.05), PME/β-NTP ratio of treated groups is lower than that of control group (P <0.05). The tumor volume between treated groups and control group showed no significant difference. Conclusion:31P MRS of mouse S180 sarcoma can offer not only quantitative information, but show also earlier response to therapy. |
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| Keywords: | 31P MRS |
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