| Abstract: | In this paper, we construct a simplified neuronal model that is capable
of simulating the instigation of cortical spreading depression (CSD) and
propagation of a CSD wave. Our model is a simplification and extension of
a single neuron model proposed in the literature for studying the instigation
of CSD. Using the simplified neuronal model, we construct a network of these
simplified neurons. This network model shows that the propagation of a CSD
wave occurs naturally after it is instigated electrically or chemically.
Although the model is simple, the speed of the CSD wave predicted by our
model is consistent with experimentally observed values. Finally, our model
allows us to investigate the effects of specific ion channels on the spread
of a CSD wave. |
