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Cytotoxic 8,9-secokaurane diterpenes from a New Zealand liverwort, Lepidolaena taylorii |
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| Authors: | Nigel B Perry Elaine J Burgess Raymond S Tangney |
| Institution: | a Plant Extracts Research Unit, New Zealand Institute for Crop & Food Research Limited, Department of Chemistry, University of Otago, Box 56, Dunedin, New Zealand b Department of Botany, University of Otago, Box 56, Dunedin, New Zealand |
| Abstract: | The main cytotoxic compound from the liverwort Lepidolaena taylorii is the known ent-8,9-seco-7-hydroxy-kaura-8(14),16-dien-9,15-dione1. The relative stereochemistry of a new cytotoxic compound, 16,17-dihydro derivative 2, was supported by molecular modelling. Another new cytotoxic compound was identified as 8,14-epoxide 3 by preparation from 1. These compounds showed differential cytotoxic activity against human tumor cell lines. |
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