Synthesis of 2-Substituted Hexahydro-1H-1,4-diazepine Analogues |
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| Authors: | Jing Shan SHEN Li Jun LEI Tie Ma YAN Jian Feng LI Hui Jun LI Zhen Hua LI Ru Yun JI |
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| Institution: | Jing Shan SHEN,Li Jun LEI,Tie Ma YAN,Jian Feng LI,Hui Jun LI,Zhen Hua LI,Ru Yun JI* Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 200031 |
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| Abstract: | substituted hexahydro-1H-1,4-diazepine analogues were synthesized starting from N,N?-dibenzyl-1,3-propylene diamine and methyl-2,3-dibromo propionate through nucleophilic substitution, reduction, chlorination and debenzylation. |
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| Keywords: | Hexahydro-1H-1 4-diazepine analogues synthesis nucleophilic substitution reduction chlorination debenzylation |
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