Thread Insertion of a Bis(dipyridophenazine) Diruthenium Complex into the DNA Double Helix by the Extrusion of AT Base Pairs and Cross‐Linking of DNA Duplexes |
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| Authors: | D Roeland Boer Lisha Wu Per Lincoln Miquel Coll |
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| Institution: | 1. Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixach 10, 08028 Barcelona (Spain);2. Institut de Biologia Molecular de Barcelona (CSIC), Baldiri Reixac 10, 08028 Barcelona (Spain);3. Department of Chemical and Biological Engineering, Chalmers University of Technology, SE‐41296 Gothenburg (Sweden) |
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| Abstract: | The crystal structure of the Δ,Δ enantiomer of the binuclear “light‐switch” ruthenium complex μ‐(11,11′‐bidppz)(1,10‐phenanthroline)4 Ru2]4+ bound to the oligonucleotide d(CGTACG) shows that one dppz moiety of the dumbbell‐like compound inserts into the DNA stack through the extrusion of an AT base pair. The second dppz moiety recruits a neighboring DNA molecule, and the complex thus cross‐links two adjacent duplexes by bridging their major grooves. |
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| Keywords: | base‐pair extrusion DNA metalloinsertors DNA threading ruthenium binuclear complexes X‐ray crystal structures |
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