α‐MsO/TsO/Cl Ketones as Oxidized Alkyne Equivalents: Redox‐Neutral Rhodium(III)‐Catalyzed CH Activation for the Synthesis of N‐Heterocycles |
| |
| Authors: | Dr. Da‐Gang Yu Francisco de Azambuja Prof. Dr. Frank Glorius |
| |
| Affiliation: | Westf?lische Wilhelms‐Universit?t Münster, Organisch‐Chemisches Institut, Corrensstrasse 40, 48149 Münster (Germany) http://www.uni‐muenster.de/Chemie.oc/glorius/ |
| |
| Abstract: | α‐Halo and pseudohalo ketones are used for the first time as C(sp3)‐based electrophiles in transition‐metal‐catalyzed C? H activation and as oxidized alkyne equivalents in RhIII‐catalyzed redox‐neutral annulations to generate diverse N‐heterocycles. This transformation is efficient and scalable. Due to the mild reaction conditions, a variety of functional groups could be tolerated. |
| |
| Keywords: | C H activation isoquinolones ketones N‐heterocycles rhodium catalysis |
|
