EBC‐219: A New Diterpene Skeleton,Crotinsulidane, from the Australian Rainforest Containing a Bridgehead Double Bond |
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| Authors: | Dr. Lidiya A. Maslovskaya Dr. Andrei I. Savchenko Dr. Elizabeth H. Krenske Carly J. Pierce Dr. Victoria A. Gordon Dr. Paul W. Reddell Prof. Peter G. Parsons Assoc.Prof. Craig M. Williams |
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| Affiliation: | 1. Queensland Institute of Medical Research, Brisbane (Australia);2. School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, 4072, Queensland (Australia) http://www.scmb.uq.edu.au/homepages/williams/index.html;3. EcoBiotics Limited, Yungaburra (Australia) |
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| Abstract: | EBC‐219 ( 4 ), isolated from Croton insularis (Baill), was established by spectroscopic and DFT methods as the first member of a new diterpene skeletal class, uniquely defined by the presence of a bicyclo[10.2.1] bridgehead olefin. The proposed biogenetic pathway to 4 from the co‐isolated natural products EBC‐131 ( 1 ), EBC‐180 ( 2 ) and EBC‐181 ( 3 ) is highly likely. EBC‐180 ( 2 ) and EBC‐181 ( 3 ) showed moderate to strong cytotoxic activity against various cancer cell lines. |
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| Keywords: | bridgehead olefins crotinsulidanes EBC‐219 natural products structure eludication |
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