Ruthenium‐Catalyzed Cascade CH Functionalization of Phenylacetophenones |
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Authors: | Dr. Vaibhav P. Mehta Dr. José‐Antonio García‐López Prof. Michael F. Greaney |
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Affiliation: | School of Chemistry, The University of Manchester, Manchester, M13 9PL (UK) |
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Abstract: | Three orthogonal cascade C? H functionalization processes are described, based on ruthenium‐catalyzed C? H alkenylation. 1‐Indanones, indeno indenes, and indeno furanones were accessed through cascade pathways by using arylacetophenones as substrates under conditions of catalytic [{Ru(p‐cymene)Cl2}2] and stoichiometric Cu(OAc)2. Each transformation uses C? H functionalization methods to form C? C bonds sequentially, with the indeno furanone synthesis featuring a C? O bond formation as the terminating step. This work demonstrates the power of ruthenium‐catalyzed alkenylation as a platform reaction to develop more complex transformations, with multiple C? H functionalization steps taking place in a single operation to access novel carbocyclic structures. |
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Keywords: | cascade chemistry C– H activation homogeneous catalysis oxidative coupling ruthenium |
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