Mild Bioconjugation Through the Oxidative Coupling of ortho‐Aminophenols and Anilines with Ferricyanide |
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| Authors: | Allie C. Obermeyer John B. Jarman Chawita Netirojjanakul Kareem El Muslemany Prof. Dr. Matthew B. Francis |
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| Affiliation: | 1. Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720‐1460 (USA);2. Materials Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (USA) |
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| Abstract: | Using a small‐molecule‐based screen, ferricyanide was identified as a mild and efficient oxidant for the coupling of anilines and o‐aminophenols on protein substrates. This reaction is compatible with thiols and 1,2‐diols, allowing its use in the creation of complex bioconjugates for use in biotechnology and materials applications. |
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| Keywords: | amines bioconjugation iron oxidation proteins |
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