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Diphenylacetylene‐Linked Peptide Strands Induce Bidirectional β‐Sheet Formation |
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| Authors: | Dr. Hannah Lingard Jeongmin T. Han Dr. Amber L. Thompson Dr. Ivanhoe K. H. Leung Dr. Richard T. W. Scott Dr. Sam Thompson Prof. Andrew D. Hamilton |
| Affiliation: | Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK) http://hamilton.chem.ox.ac.uk |
| Abstract: | In the search for synthetic mimics of protein secondary structures relevant to the mediation of protein–protein interactions, we have synthesized a series of tetrasubstituted diphenylacetylenes that display β‐sheet structures in two directions. Extensive X‐ray crystallographic and NMR solution phase studies are consistent with these proteomimetics adopting sheet structures, displaying both hydrophobic and hydrophilic amino acid side chains. |
| Keywords: | beta‐sheets peptidomimetics protein surfaces protein‐protein interactions secondary structures |