Guest‐Adaptable and Water‐Stable Peptide‐Based Porous Materials by Imidazolate Side Chain Control |
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| Authors: | Dr Alexandros P Katsoulidis Dr Kyo Sung Park Dr Dmytro Antypov Dr Carlos Martí‐Gastaldo Dr Gary J Miller Dr John E Warren Dr Craig M Robertson Dr Frédéric Blanc Dr George R Darling Dr Neil G Berry Dr John A Purton Dr Dave J Adams Prof Matthew J Rosseinsky |
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| Institution: | 1. Department of Chemistry, University of Liverpool, Crown Street, Liverpool, L69 7ZD (UK);2. Daresbury Laboratory, Science & Technologies Facilities Council, Kerkwick Lane, Warrington, WA4 4AD (UK) |
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| Abstract: | The peptide‐based porous 3D framework, ZnCar, has been synthesized from Zn2+ and the natural dipeptide carnosine (β‐alanyl‐L ‐histidine). Unlike previous extended peptide networks, the imidazole side chain of the histidine residue is deprotonated to afford Zn–imidazolate chains, with bonding similar to the zeolitic imidazolate framework (ZIF) family of porous materials. ZnCar exhibits permanent microporosity with a surface area of 448 m2 g?1, and its pores are 1D channels with 5 Å openings and a characteristic chiral shape. This compound is chemically stable in organic solvents and water. Single‐crystal X‐ray diffraction (XRD) showed that the ZnCar framework adapts to MeOH and H2O guests because of the torsional flexibility of the main His‐β‐Ala chain, while retaining the rigidity conferred by the Zn–imidazolate chains. The conformation adopted by carnosine is driven by the H bonds formed both to other dipeptides and to the guests, permitting the observed structural transformations. |
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| Keywords: | imidazolates metal– organic frameworks microporous materials peptides structural adaptability |
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