|
|||||
|
|
Palladium‐Catalyzed Oxidative Carbonylation of N‐Allylamines for the Synthesis of β‐Lactams |
|
| Authors: | Wu Li Dr Chao Liu Prof Heng Zhang Keyin Ye Guanghui Zhang Wangzheng Zhang Zhengli Duan Prof Shuli You Prof Aiwen Lei |
| Institution: | 1. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, (P. R. China) http://aiwenlei.whu.edu.cn/Main_Website/;2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai, 200032 (China);3. National Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, Jiangxi (P. R. China) |
| Abstract: | β‐Lactam scaffolds are considered to be ideal building blocks for the synthesis of nitrogen‐containing compounds. A new palladium‐catalyzed oxidative carbonylation of N‐allylamines for the synthesis of α‐methylene‐β‐lactams is reported. DFT calculations suggest that the formation of β‐lactams via a four‐membered‐ring transition state is favorable. |
| Keywords: | allylic compounds heterocycles lactams palladium synthetic methods |