Highly Chemo‐, Regio‐, and Enantioselective Rhodium‐Catalyzed Cross‐Cyclotrimerization of Two Different Alkynes with Alkenes |
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| Authors: | Jun Hara Mana Ishida Masayuki Kobayashi Prof. Dr. Keiichi Noguchi Prof. Dr. Ken Tanaka |
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| Affiliation: | 1. Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184‐8588 (Japan) http://www.tuat.ac.jp/～tanaka‐k/;2. Instrumentation Analysis Center, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184‐8588 (Japan);3. Japan Science and Technology Agency (JST), ACT‐C, 4‐1‐8 Honcho, Kawaguchi, Saitama, 332‐0012 (Japan) |
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| Abstract: | It has been established that a cationic rhodium(I)/(R)‐tol‐binap complex catalyzes the cross‐cyclotrimerization of silylacetylenes, di‐tert‐butyl acetylenedicarboxylates, and acrylamides with excellent chemo‐, regio‐, and enantioselectivities. Unsymmetrical alkynoates can also be employed in place of di‐tert‐butyl acetylenedicarboxylate for this process, but with reduced chemoselectivity. |
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| Keywords: | alkenes alkynes asymmetric catalysis cyclotrimerization multicomponent reactions rhodium |
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