Palladium‐Catalyzed ortho‐Selective CH Deuteration of Arenes: Evidence for Superior Reactivity of Weakly Coordinated Palladacycles |
| |
| Authors: | Dr Sandy Ma Dr Giorgio Villa Peter S Thuy‐Boun Anna Homs Prof Dr Jin‐Quan Yu |
| |
| Institution: | Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) http://www.scripps.edu/chem/yu |
| |
| Abstract: | We disclose a protocol for the palladium‐catalyzed ortho‐selective C? H deuteration of arenes. Phenylacetic acids and benzoic acids are suitable substrates for this reaction. This reaction offers a catalytic route to ortho‐deuterated phenylacetic acids and benzoic acids and demonstrates the sharp difference in reactivity of palladacycle intermediates held together by weak and strong coordination. |
| |
| Keywords: | C H activation deuteration palladium phenylacetic acids weak coordination |
|
