Direct UV‐Induced Functionalization of Surface Hydroxy Groups by Thiol–Ol Chemistry |
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| Authors: | Linxian Li Junsheng Li Xin Du Dr Alexander Welle Prof Dr Michael Grunze Prof Dr Oliver Trapp Dr Pavel A Levkin |
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| Institution: | 1. Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology (KIT), 76344 Karlsruhe (Germany);2. Department of Organic Chemistry, University of Heidelberg (Germany);3. Department of Applied Physical Chemistry, University of Heidelberg (Germany);4. Institute of Functional Interfaces (IFG), KIT (Germany) |
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| Abstract: | A novel UV‐initiated surface modification method for the direct functionalization of surface hydroxy groups with thiol‐containing molecules (termed “thiol–ol” modification) is described. This method is based on the oxidative conjugation of thiols to hydroxy groups. We demonstrate that different thiol‐containing molecules, such as fluorophores, thiol‐terminated poly(ethylene glycol) (PEG‐SH), and a cysteine‐containing peptide, can be attached onto the surface of porous poly(2‐hydroxyethyl methacrylate‐co‐ethylene dimethacrylate). Direct functionalization of other hydroxy‐group‐bearing surfaces, fabrication of micropatterns, and double patterning have been also demonstrated using the thiol–ol method. |
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| Keywords: | alcohols photopatterning photochemistry surface chemistry thiols |
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