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Catalytic Enantioselective Oxidative Cross‐Coupling of Benzylic Ethers with Aldehydes |
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| Authors: | Zhilin Meng Shutao Sun Prof. Dr. Huiqing Yuan Prof. Dr. Hongxiang Lou Prof. Dr. Lei Liu |
| Affiliation: | 1. Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012 (P. R. China);2. Department of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan 250012 (P. R. China) |
| Abstract: | The first one‐pot enantioselective oxidative coupling of cyclic benzylic ethers with aldehydes has been developed. A variety of benzylic ethers were transformed into the corresponding oxygen heterocycles with high enantioselectivity. Mechanistic experiments were conducted to determine the nature of the reaction intermediates. The application of this strategy to coupling reactions with other nucleophiles besides aldehydes was also explored. |
| Keywords: | aldehydes asymmetric catalysis benzylic ethers C H functionalization organocatalysis |