Ligand‐Controlled α‐ and β‐Arylation of Acyclic N‐Boc Amines |
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| Authors: | Anthony Millet David Dailler Dr Paolo Larini Prof?Dr Olivier Baudoin |
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| Institution: | Université Claude Bernard Lyon 1, CNRS UMR 5246, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, CPE Lyon, 43 Boulevard du 11 Novembre 1918, Lyon (France) http://cosmo.univ‐lyon1.fr/Index.html |
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| Abstract: | The palladium‐catalyzed ligand‐controlled arylation of α‐zincated acyclic amines, obtained by directed α‐lithiation and transmetalation, is described. Whereas PtBu3 gave rise to α‐arylated Boc‐protected amines, more flexible N‐phenylazole‐based phosphine ligands induced major β‐arylation through migrative cross‐coupling. |
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| Keywords: | arylation C C coupling cross‐coupling density functional calculations palladium |
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