Abstract: | The review gives methods of synthesizing the biocatalyst biotin. The existing methods of obtaining biotin and its stereoisomers from dihaloalkanes, dicarboxylic acid esters, sugars, thiophene derivatives, etc., are discussed. The basic possibilities of the formation of biotin are considered.All-Union Scientific-Research Vitamin Institute. Translated from Khimiya Pridodnykh Soedinenii, No. 4, pp. 445–477, July–August, 1980. |