A controlled release of ibuprofen by systematically tailoring the morphology of mesoporous silica materials |
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| Authors: | Fengyu Qu Guangshan Zhu Jinyu Sun Shilun Qiu |
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| Institution: | a State Key Laboratory for Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130023, China
b Chemistry and Pharmaceutical College, Jiamusi University, Jiamusi 154007, China |
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| Abstract: | A series of mesoporous silica materials with similar pore sizes, different morphologies and variable pore geometries were prepared systematically. In order to control drug release, ibuprofen was employed as a model drug and the influence of morphology and pore geometry of mesoporous silica on drug release profiles was extensively studied. The mesoporous silica and drug-loaded samples were characterized by X-ray diffraction, Fourier transform IR spectroscopy, N2 adsorption and desorption, scanning electron microscopy, and transmission electron microscopy. It was found that the drug-loading amount was directly correlated to the Brunauer-Emmett-Teller surface area, pore geometry, and pore volume; while the drug release profiles could be controlled by tailoring the morphologies of mesoporous silica carriers. |
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| Keywords: | Mesoporous silica Morphology Ibuprofen Controlled release |
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