BSA和SDBS在水溶液与空气界面的相互作用

表面活性剂与蛋白质在界面处的相互作用在许多应用里都会遇到．如去污、药品或生物制剂的制备和提纯、某些开科手术等等[1]这常常涉及到表面活性剂与蛋白质在界面的吸附，蛋白质大分子在界面吸附层的取向和构象．对于这两种物质在界面处可能发生的相互作用的性质，是表面活性剂

Interaction between BSA and SDBS at Water-air Interface by ADSA Method

The interaction between BSA (Bovine Serium Albumin)and SDBS (Sodium Do-decyl Benzene sulfonate) at water - air interface of aqueous solution was investigated byADSA(Axisymmetric Drop Shape Analysis) method. The surface tension responses to time weremeasured and compared. The results showed that (1) ADSA is a good methed to study the dy-namic change of surface tellsion to the time; (2) While SDBS concentration was less than its CMC,it could interact with BSA macro-molecule in the solution to form a complex which was moresurface active than both BSA and SDBS, and its conformation change in the adsorption layer wassimilar with that of BSA alone, (3) While SDBS concentration was larger than its CMC, its micellecould solubilize the BSA macro-molecule and the surface tension and the conformation change inthe adsorption layer was very similar with these of SDBS solution alone.