| 邻氨基苯硫基-1-丙酮缩合反应动力学及机理 |
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| 引用本文： | 李媛,黄保华,吕迎潮,金声,邢其毅. 邻氨基苯硫基-1-丙酮缩合反应动力学及机理[J]. 物理化学学报, 1998, 14(11): 1048-1052. DOI: 10.3866/PKU.WHXB19981117 |
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| 作者姓名： | 李媛 黄保华 吕迎潮 金声 邢其毅 |
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| 作者单位： | Chemistry Department,Hebei Normal University,Shijiazhuang 050016,Institute of Chemistry and Molecular Engineering,Peking University,Beijing 100871 |
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| 摘 要： | 1，5-苯并硫氮杂（Ⅱ）是一类重要的七元杂环化合物，具有明显的生理活性．多年来，其合成、结构及药理活性的研究一直受到广泛关注[1-5]．（Ⅱ）通常由1，3-二烃基-3-邻氨基苯硫基-1-丙酮（简称氨基酮）分子内缩合反应合成．本文用紫外分光光度法结合核磁共振监测反应中间过程
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| 关 键 词： | 1 5-苯并硫氮杂 缩合反应 动力学 机理 |
| 收稿时间： | 1997-12-01 |
| 修稿时间： | 1998-04-01 |
The Mechanism and Kinetics of Intramolecular Condensation Reaction of 1,3-Diaryl-3-(2-amino-phenylsulfenyl)-propan-1-one |
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| Li Yuan. The Mechanism and Kinetics of Intramolecular Condensation Reaction of 1,3-Diaryl-3-(2-amino-phenylsulfenyl)-propan-1-one[J]. Acta Physico-Chimica Sinica, 1998, 14(11): 1048-1052. DOI: 10.3866/PKU.WHXB19981117 |
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| Authors: | Li Yuan |
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| Affiliation: | Chemistry Department,Hebei Normal University,Shijiazhuang 050016|Institute of Chemistry and Molecular Engineering,Peking University,Beijing 100871 |
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| Abstract: | The kinetics and mechanism of intramolecular condensation of amino ketones catalyzed respectively by sly acids in methanol solution were studied by means of UV spectroscopy and 1H NMR.The results indicate that the reaction proceeds with a general acid catalytic mechanism in the presence of acetic arid, and in lactic arid, in other stronger arids-methanol solution, the mechanism is of a special arid catalytic one. The result also shows that R2 has an effect on the reaction rate. |
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| Keywords: | 1.5-benzothiazepine Condensation reaction Kinetics Mechanism |
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