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Preparation of TMS protected trifluoromethylated alcohols using trimethylamine N-oxide and trifluoromethyltrimethylsilane (TMSCF3) |
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| Authors: | G.K.Surya Prakash Mihirbaran Mandal Chiradeep Panja Thomas Mathew George A. Olah |
| Affiliation: | Donald P. and Katherine B. Loker Hydrocarbon Research Institute, Department of Chemistry, University of Southern California, University Park, Los Angeles, CA 90089-1661, USA |
| Abstract: | A catalytic trifluoromethylation of aldehydes using trimethylamine N-oxide and trifluoromethyltrimethylsilane (TMSCF3) is described. Aromatic, aliphatic and α,β-unsaturated aldehydes provided good to excellent yields of the corresponding trifluoromethylated products. |
| Keywords: | Aldehydes Trifluoromethyltrimethylsilane Trimethylamine N-oxide Catalytic CF3 transfer Nucleophilic trifluoromethylation |
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