| 新型8-羟基喹啉席夫碱的合成与抑菌活性 |
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| 引用本文： | 颜世娜,张敬,赵斌,李桂芝,范娜. 新型8-羟基喹啉席夫碱的合成与抑菌活性[J]. 广州化学, 2009, 34(3) |
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| 作者姓名： | 颜世娜 张敬 赵斌 李桂芝 范娜 |
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| 作者单位： | 曲阜师范大学化学系,山东曲阜,273165;济宁师范专科学校化学系,山东济宁,273115;曲阜师范大学生物系,山东曲阜,273165 |
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| 基金项目： | 山东省曲阜师范大学科研启动基金资助项目 |
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| 摘 要： | 以2-甲基-8-羟基喹啉为原料,经羟基保护、甲基氧化、水解后得到2-甲酰基-8-羟基喹啉(L)。L分别与苯胺衍生物缩合得到三种新型喹啉衍生物。经元素分析、红外光谱、紫外光谱、核磁共振谱表征,确定了席夫碱的组成。产物分别与大肠杆菌、产气杆菌、枯草杆菌、变形杆菌、金黄色葡萄球菌进行抑菌活性实验,配体与席夫碱均有较好的抑菌活性。
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| 关 键 词： | 8-羟基喹啉 席夫碱 抑菌活性 |
Synthesis and Antibacterial Activity of New Schiff Base Type Derivatives of 8-Hydroxyquinoline |
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| YAN Shi-Na,ZHANG Jing,ZHAO Bin,LI Gui-zhi,FAN Na. Synthesis and Antibacterial Activity of New Schiff Base Type Derivatives of 8-Hydroxyquinoline[J]. Guangzhou Chemistry, 2009, 34(3) |
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| Authors: | YAN Shi-Na ZHANG Jing ZHAO Bin LI Gui-zhi FAN Na |
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| Affiliation: | 1. Chemistry Department of Qufu Normal University;2. Biology Department of Qufu Normal University;Qufu 273165;China;3. Chemistry Department of Jining Teacher's College;Jining 273155;China |
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| Abstract: | 2-methyl-8-hydroxyquinoline was protected the hydroxyl group,followed by oxidation and hydrolyzation to obtain 2-formyl-8-hydroxyquinoline. Three schiff base type derivatives of 8-hydroxyquinoline were synthesized by the reaction of 2-formyl-8-hydroxyquinoline with aniline derivatives. These compounds were identified by the data of EA,IR,UV,1H NMR and 13C NMR. The antibacterial activity of 2-formyl-8-hydroxyquinoline and schiff base type derivatives of 8-hydroxyquinoline were determined. The results showed ... |
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| Keywords: | 8-hydroxyquinoline schiff base antibacterial activity |
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