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Statistical inference for right-censored data with nonignorable missing censoring indicators
Authors:ZhiHua Sun  TianFa Xie  Hua Liang
Institution:1. School of Mathematical Sciences, Graduate University of Chinese Academy of Sciences, Beijing, 100049, China
2. College of Applied Sciences, Beijing University of Technology, Beijing, 100124, China
3. Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, 14642, USA
Abstract:We consider the statistical inference for right-censored data when censoring indicators are missing but nonignorable, and propose an adjusted imputation product-limit estimator. The proposed estimator is shown to be consistent and converges to a Gaussian process. Furthermore, we develop an empirical process-based testing method to check the MAR (missing at random) mechanism, and establish asymptotic properties for the proposed test statistic. To determine the critical value of the test, a consistent model-based bootstrap method is suggested. We conduct simulation studies to evaluate the numerical performance of the proposed method and compare it with existing methods. We also analyze a real data set from a breast cancer study for an illustration.
Keywords:
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