Silyl Modification of Biologically Active Compounds. 10. Lipid Type Organosilicon Derivatives of 8-Hydroxyquinoline and N-(2-Hydroxyethyl)-1,2,3,4-tetrahydro(sila,iso)quinolines

Organosilicon alkylation of the primary alcoholic groups of N-(2-hydroxyalkyl) derivatives of 1,2,3,4-tetrahydroquinoline, tetrahydroisoquinoline, and 4,4-dimethyltetrahydro-4-silaisoquinoline, and also the hydroxyl group of 8-hydroxyquinoline by trialkyl-chloroalkylsilanes under conditions of phase-transfer catalysis has been investigated. The neurotropic properties and acute toxicity of the synthesized compounds have been investigated.__________Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 713–725, May, 2005.