| Three New Coumarins from Micromelum integerrimum |
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| 引用本文： | Hong Ping HE,1 Yun ZOU,2 Yue Mao SHEN,1 Xiao Yan HAO,2 Guo Yin ZUO,1 Xiao Jiang HAO1,3* 1Laboratory of Phytochemistry,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204. 2Department of Medicinal Chemistry,Guiyang Medical College. Three New Coumarins from Micromelum integerrimum[J]. 中国化学快报, 2001, 0(7) |
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| 作者姓名： | Hong Ping HE 1 Yun ZOU 2 Yue Mao SHEN 1 Xiao Yan HAO 2 Guo Yin ZUO 1 Xiao Jiang HAO1 3* 1Laboratory of Phytochemistry Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204. 2Department of Medicinal Chemistry Guiyang Medical College |
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| 作者单位： | Hong Ping HE，1 Yun ZOU，2 Yue Mao SHEN，1 Xiao Yan HAO，2 Guo Yin ZUO，1 Xiao Jiang HAO1，3* 1Laboratory of Phytochemistry，Kunming Institute of Botany，Chinese Academy of Sciences，Kunming 650204. 2Department of Medicinal Chemistry，Guiyang Medical College |
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| 摘 要： | Micromelum integerrimum (Rutaceae) is a shrub growing in Yunnan Province. Leaves and barks of this plant have been used for the treatment of dysentery, and arthritis1. Previous researches revealed that this plant contained coumarins2-8. Micromelin, the main chemical constituent of this plant, showed significant inhibition against leukaemia P-388 cell line (T/C 149% at 10 mg/kg) but was inactive in lower doses, and also showed significant activity (T/C 228% at 1.25 mg/kg) against Lewis lung…
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Three New Coumarins from Micromelum integerrimum |
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| Hong Ping HE, Yun ZOU, Yue Mao SHEN, Xiao Yan HAO, Guo Yin ZUO, Xiao Jiang HAO, Laboratory of Phytochemistry,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming. Three New Coumarins from Micromelum integerrimum[J]. Chinese Chemical Letters, 2001, 0(7) |
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| Authors: | Hong Ping HE Yun ZOU Yue Mao SHEN Xiao Yan HAO Guo Yin ZUO Xiao Jiang HAO Laboratory of Phytochemistry Kunming Institute of Botany Chinese Academy of Sciences Kunming |
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| Affiliation: | Hong Ping HE,1 Yun ZOU,2 Yue Mao SHEN,1 Xiao Yan HAO,2 Guo Yin ZUO,1 Xiao Jiang HAO1,3* 1Laboratory of Phytochemistry,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204. 2Department of Medicinal Chemistry,Guiyang Medical College |
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| Abstract: | Three derivatives of micromelin, named hydramicromelins A-C (1-3), were isolated from the aerial part of Micromelum integerrimum (Buch.-Ham) Roem., respectively. Hydramicromelins A-C (1-3) were epimers which possessed the same plane structure and molecular formula. Their structures were elucidated based on MS and NMR data. The relative configurations of 1-3 were established by NOE analysis. |
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| Keywords: | Micromelum integerrimum Rutaceae coumarin micromelin hydramicromelins A-C. |
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