Recent Advances in Renal Clearable Inorganic Nanoparticles for Cancer Diagnosis |
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Authors: | Ruiqi Yin Xiaochen Zhang Jianxian Ge Ling Wen Lei Chen Jianfeng Zeng Zhen Li Mingyuan Gao |
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Institution: | 1. Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou, 215123 China;2. Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, 215006 China;3. Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou, 215123 China
Shanghai University of Medicine and Health Sciences (SUMHS), Shanghai, 201318 China |
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Abstract: | The rapid growth of inorganic nanoparticles provides numerous opportunities for cancer diagnosis. Due to their adjustable and diverse characteristics that are strongly dependent on the size, morphology, charge, and the nature of surface coatings, they are widely used in the field of oncology. However, inorganic nanomaterials are usually difficult to degrade and excrete within a short time, resulting in long-term in vivo retention and potential toxicity, which significantly hinders their translation into clinical practice. Therefore, the development of renal clearable inorganic nanomaterials that can excrete out of body within desired timeframe is of great significance to promote their clinical bioapplications. Herein, the recent advances in renal clearable inorganic nanoparticles for tumor diagnosis are focused on, and the factors affecting the renal clearance efficiency, with a view to understand the underlying metabolism mechanism and the relevant bioapplications, are discussed. |
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Keywords: | cancer diagnosis inorganic nanoparticles molecular imaging nanomedicine renal clearance |
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