|
|||||
|
|
A Photolabile Carboxyl Protecting Group for Solid Phase Peptide Synthesis |
|
| Authors: | Hongpeng Yang Prof. Tao Peng Prof. Xiaoxue Wen Tingting Chen Prof. Yunbo Sun Prof. Shuchen Liu Gang Wang Prof. Shouguo Zhang Prof. Lin Wang |
| Affiliation: | 1. Faculty of Environment & Life, Beijing University of Technology, Beijing, 100124 China Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing, 100850 China;2. Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing, 100850 China;3. Faculty of Environment & Life, Beijing University of Technology, Beijing, 100124 China |
| Abstract: | A new kind of photolabile protecting group (PLPG) for carboxyl moieties was designed and synthesized as the linker between resin and peptide. This group can be used for the protection of amino acid carboxyl groups. The peptide was synthesized on Nph (2-hydroxy-3-(2-nitrophenyl)-heptanoic acid)-derivatized resins and could be cleaved under UV exposure, thus avoiding the necessity for harsh acid-mediated resin cleavage. The PLPG has been successfully used for solid-phase synthesis of peptides. |
| Keywords: | linker molecules peptides protecting groups photolabile compounds solid-phase synthesis |