Structure elucidation and vasodilator activity of methoxy flavonols from Calycotome villosa subsp. intermedia |
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| Authors: | Ali El Antri Nadya Lachkar Hanane El Hajjaji Farah Gaamoussi Badiaa Lyoussi Brahim El Bali Nicole Morel Hassan Allouchi Mohammed Lachkar |
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| Institution: | 1. Laboratoire d’Ingénierie des Matériaux Organométalliques et Moléculaires “L.I.M.O.M.”, Unité associée au CNRST (URAC 19) Département de Chimie, Faculté des Sciences, Université Sidi Mohamed Ben Abdellah, B.P. 1796 (Atlas), 30000 Fès, Morocco;2. UFR Physiologie Pharmacologie, Faculté des Sciences, Université Sidi Mohamed Ben Abdellah, B.P. 1796 (Atlas), 30000 Fès, Morocco;3. Laboratory of Mineral Solid and Analytical Chemistry, “LMSAC”, Department of Chemistry, Faculty of Sciences, University Mohamed I, P.O. Box 717, 60000 Oujda, Morocco;4. Laboratoire de Pharmacologie UCL 5410 Avenue Hippocrate 54, B1200 Brussels, Belgium;5. Laboratoire de Chimie Physique, Faculté de Pharmacie, SPOT E.A. 3857, 31 Avenue Monge, 37200 Tours, France |
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| Abstract: | Two flavonols identified as 3,5,7,4′-tetrahydroxy-3′-methoxyflavone (1) and 3,5,7,4′-tetrahydroxy-8-methoxyflavone (2) were isolated from the seeds of Calycotome villosa subsp. intermedia. The structure elucidation of the isolated compounds was performed by the spectroscopic methods (UV, IR, 1H NMR, 13C NMR and MS) and also by a single crystal X-ray analysis in the case of compound (2). Vasodilator activity of compound (2) was demonstrated in isolated rat aorta contracted with high KCl or with noradrenaline. |
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| Keywords: | Flavonols Spectroscopy X-ray crystal structure determination Vasodilator activity Rat aorta |
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