Efficient synthesis of 4-aminoquinazoline and thieno[3,2-d]pyrimidin-4-ylamine derivatives by microwave irradiation |
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Authors: | Yoon David S Han Ying Stark Todd M Haber James C Gregg Brian T Stankovich Sara B |
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Affiliation: | Albany Molecular Research, Inc., 21 Corporate Circle, Albany, New York 12212-5098, USA. |
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Abstract: | [reaction: see text] A simple, efficient, and high-yielding synthesis of quinazolin-4-ylamine and thieno[3,2-d]pyrimidin-4-ylamine derivatives is reported under microwave irradiation conditions. Reaction conditions including temperature, solvent, and reaction time have been studied. An efficient parallel workup procedure was developed to generate a small library (23 compounds) in a short time period. |
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