Template synthesis, spectroscopic studies and biological screening of macrocyclic complexes derived from thiocarbohydrazide and benzil |
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Authors: | Dharam P Singh Ramesh Kumar Parikshit Tyagi |
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Institution: | (1) Department of Chemistry, National Institute of Technology, Kurukshetra, 136 119, India;(2) Serum Institute of India Ltd., 212/2, Hadapsar, Pune, 411 028, India |
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Abstract: | A novel series of complexes of the type M(TML)X2]; where TML is a tetradentate macrocyclic ligand; M = Co(II), Ni(II), Cu(II) or Zn(II); X = Cl−, CH3COO− or NO
3
−
have been synthesized by template condensation of benzil and thiocarbohydrazide in the presence of divalent metal salts in
methanolic medium. The complexes have been characterized with the help of elemental analyses, conductance measurements, molecular
weight determination, magnetic measurements, electronic, NMR, infrared and far infrared spectral studies. Electronic spectra
along with magnetic moments suggest the six coordinate octahedral geometry for these complexes. The low value of molar conductance
indicates them to be non-electrolytes. The biological activities of metal complexes have been tested in vitro against a number of pathogenic bacteria to assess their inhibiting potential. |
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