Soluble perlecan domain i enhances vascular endothelial growth factor-165 activity and receptor phosphorylation in human bone marrow endothelial cells |
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| Authors: | Arivalagan Muthusamy Carlton R Cooper Jr" target="_blank">Ronald R GomesJr |
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| Institution: | (1) Department of Orthopaedics and Rehabilitation, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA;(2) Department of Biological Sciences, Center for Translational Cancer Research, University of Delaware, Newark, Delaware 19716, USA |
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| Abstract: | Background Immobilized recombinant perlecan domain I (PlnDI) binds and modulates the activity of heparin-binding growth factors, in vitro. However, activities for PlnDI, in solution, have not been reported. In this study, we assessed the ability of soluble forms
to modulate vascular endothelial growth factor-165 (VEGF165) enhanced capillary tube-like formation, and VEGF receptor-2 phosphorylation of human bone marrow endothelial cells, in vitro. |
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