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Discovery of novel sesquiterpenoids from a gorgonian Menella sp. |
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| Authors: | Shih-Yao Kao Jui-Hsin Su Tsong-Long HwangJyh-Horng Sheu Yin-Di Su Chan-Shing Lin Yu-Chia Chang Wei-Hsien Wang Lee-Shing FangPing-Jyun Sung |
| Affiliation: | a Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan b National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan c Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan d Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan e Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan f Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan g Department of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan h Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan |
| Abstract: | A novel sesquiterpenoid, menelloide A (1), which was found to possess a new carbon skeleton, and a new guaiane-type sesquiterpenoid, menelloide B (2), along with (+)-chloranthalactone B (3), an enantiomer of the known sesquiterpenoid, chloranthalactone B (4), were isolated from a gorgonian coral identified as Menella sp. The structures of sesquiterpenoids 1-3 were established by spectroscopic methods and by comparison of the data with those of related metabolites. Sesquiterpenoids 1 and 3 displayed inhibitory effects on the generation of superoxide anion by human neutrophils. |
| Keywords: | Sesquiterpenoid Menella Menelloide Guaiane Superoxide anion |
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