Palladium-catalyzed acylation and/or homo-coupling of aryl- and alkyl-acetylenes |
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Authors: | Serena PerroneFabio Bona Luigino Troisi |
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Institution: | Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, University of Salento, Via Prov.le Lecce-Monteroni, 73100 Lecce, Italy |
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Abstract: | Allyl or benzyl halides, through a Pd(0)-catalyzed reaction and under CO pressure, generate acyl-palladium/halides that, in the presence of a base and an aryl- and alkyl-acetylene, undergo nucleophilic acyl substitution giving conjugated acetylenic ketones. Diynes, resulting from alkyne/alkyne homo-coupling, were instead the main products in reactions performed without allyl or benzyl halides. Moreover, dimerization, trimerization, and cyclotrimerization reactions of acetylenes were observed in reaction carried out even without base. |
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Keywords: | Palladium Acylation Acetylenic ketones Homo-coupling Diynes |
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