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Crystal and molecular structure of chloramphenicol
Authors:C. Chatterjee  J. K. Dattagupta  N. N. Saha  W. Saenger  K. Müller
Affiliation:(1) Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, 700 009 Calcutta, India;(2) Abt. Chemie, Max Plank Institut fur Experimentelle Medizin, D-3400 Gotingen, B. R. D.
Abstract:Chloramphenicol, C11H12Cl2N2O5, is orthorhombic, space groupC2221,a = 17.495(3),b = 7.321(2),c = 22.130(4) Å, andZ = 8. The structure was solved by direct methods and refined to a finalR value of 0.068 for 1186 counter-reflections. Estimated standard deviations for bond lengths and bond angles involving nonhydrogen atoms average 0.009 Å and 0.6 °, respectively. All the hydrogen atoms that are bonded to O or N and are available for hydrogen-bond formation take part in the hydrogen-bonding network. The crystals become brown in color on prolonged exposure to X-rays and gamma-rays. Our structural investigation with colored crystal does not indicate any structural change.
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