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| 1,4-二氢吡啶衍生物的合成方法改进 | |
| 引用本文： | 王建平,杜美菊,付永举,王建革,李宁,郑爱霞.1,4-二氢吡啶衍生物的合成方法改进[J].合成化学,2007,15(1):42-45. |
| 作者姓名： | 王建平 杜美菊 付永举 王建革 李宁 郑爱霞 |
| 作者单位： | 1. 洛阳师范学院,化学系,河南,洛阳,471022 2. 商丘师范学院,化学系,河南,商丘,476000 3. 河南科技大学,化工与制药学院,河南,洛阳,471003 |
| 基金项目： | 洛阳师范学院重点学科资助课题 |
| 摘 要： | 采用改进的Hantzsch反应,在氮气保护下的封闭体系中回流芳香醛、乙酰乙酸乙酯和NH4HCO3,合成了1,4-二氢吡啶衍生物(1a~1d),其结构经1HNMR,IR和元素分析确认。用XRD测定了1b的晶体结构。 |
| 关 键 词： | 二氢吡啶 Hantzsch反应 方法改进 合成 |
| 文章编号： | 1005-1511（2007）01-0042-04 |
| 收稿时间： | 2006-02-26 |
| 修稿时间： | 2006年2月26日 |
Improvement on the Synthesis of 1,4-Dihydropyridine Derivatives |
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| WANG Jian-ping,DU Mei-ju,FU Yong-ju,WANG Jian-ge,LI Ning,ZHENG Ai-xia.Improvement on the Synthesis of 1,4-Dihydropyridine Derivatives[J].Chinese Journal of Synthetic Chemistry,2007,15(1):42-45. | |
| Authors: | WANG Jian-ping DU Mei-ju FU Yong-ju WANG Jian-ge LI Ning ZHENG Ai-xia |
| Abstract: | 1,4-Dihydropyridine derivatives(1a~1d) were synthesized by improved Hantzsch reaction of aromatic aldehyde, ethyl acetoacetate and NH4HCO3 in a closed system filled with nitrogen gas under refluxing. The structures were confirmed by 1H NMR, IR and elemental analysis. The crystal structure of 1b was determined by XRD. |
| Keywords: | dihydropyridine Hantzsch reaction improved method synthesis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |